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Neurotoxic effects of micro- and nanoplastics


Exposure to micro- and nanoplastics is unavoidable and ample evidence indicates that micro- and nanoplastics can be taken up by various organisms. While data indicate that micro- and nanoplastics can reach the brain, only limited information is available regarding the number of particles that reaches the brain and the potential neurotoxicity of these small plastic particles. This review by PrĂ¼st et al. highlights the neurotoxicity of metal and metal-oxide nanoparticles as a starting point to summarize the current evidence regarding the potential neurotoxicity of micro- and nanoplastics. The available data indicate that, analogous to metal and metal-oxide nanoparticles, exposure to micro- and nanoplastics can result in a range of neurotoxic effects, including oxidative stress, inhibition of acetylcholinesterase activity, altered neurotransmitter levels and behavioral changes (Particle and Fibre Toxicology).