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Hazard characterization of synthetic cathinones

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Zwartsen et al. investigated the acute neurotoxiceffects of several synthetic cathinones. Using a range of techniques, this study shows that synthetic cathinones inhibit the function of human dopamine, norepinephrine, and serotonin reuptake transporters. Moreover, synthetic cathinones also inhibit spontaneous neuronal activity in rat primary cortical cultures grown on microelectrode arrays (MEAs), albeit at higher concentrations. The current data indicates that synthetic cathinones with either a pyrrolidine moiety or long alkyl-tail carbon chain more potently inhibit dopamine uptake and neuronal activity, whereas norepinephrine uptake was most potently inhibited by synthetic cathinones with a pyrrolidine moiety (Frontiers in Neuroscience).