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Human iPSC-derived neuronal models for in vitro seizure liability assessment

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Tukker et al. tested three different hiPSC-derived neuronal models for their applicability for in vitro seizure liability assessment. All models develop functional neuronal networks that exhibit spontaneous activity and (network) bursting behavior. Neuronal activity and (network) bursting could be reproducibly modulated with the seizurogenic compounds strychnine, picrotoxin and 4-aminopyridine. Importantly, compared to rat primary cortical neurons, the hiPSC-derived neuronal models were equally suited to detect seizurogenicity, indicating that hiPSC-derived neuronal models may in the future be used as a first screening tool for in vitro seizure liability assessment (ALTEX).