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Differential effects of psychoactive substances on wildtype and polymorphic dopamine transporters

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Zwartsen et al. investigated the effects of 10 psychoactive substances on dopamine uptake by wildtype and polymorphic human dopamine reuptake transporters (hDAT). Both transporters are inhibited by psychoactive substances. However, compared to WT hDAT, bupropion, methylphenidate, cocaine, and MXE less potently inhibited DA uptake by the polymorphic T356 M hDAT, while citalopram more potently inhibited uptake. The T356 M polymorphism may thus affect treatment efficiency with these substances as well as susceptibly for toxicity and addiction (Toxicology).