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TUBE: Effects of traffic-derived nanoparticles on lung and brain function

TUBE: Effects of traffic-derived nanoparticles on lung and brain function

Recently our collaborative H2020 research proposal ‘Transport-derived Ultrafines and Brain Effects’ (TUBE) was granted by the European commission!

It is well-known that air pollutants can exert adverse health effects, including respiratory (e.g. asthma, COPD) and cardiovascular (ischemic heart disease, infarction, stroke) diseases. Recent evidence indicates that these adverse health effects may also extend to the brain. The TUBE consortium therefore aims to reveal the potential adverse effects of transport-derived ultrafine- or nanoparticles on lung and brain health.

Within TUBE, we will study effects of transport-derived ultrafine- or nanoparticles using in vitro models for the lung using Air-Liquid Interface (ALI) culture methods to mimic realistic human exposure. Importantly, effluents from the ALI-culture system will be used in comparison to direct exposure to ultrafine- or nanoparticles for subsequent neurotoxicity testing using human and rodent in vitro brain models. The unique combination of in vitro models will allow for a better and more realistic insight in the potential human health effects of transport-derived ultrafine- or nanoparticles.