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ENDpoiNTs: Effects of endocrine disrupting chemicals on brain development

ENDpoiNTs: Effects of endocrine disrupting chemicals on brain development

Recently our collaborative H2020 research proposal ‘Novel Testing Strategies for Endocrine Disruptors in the Context of Developmental NeuroToxicity’ (ENDpoiNTs) was granted by the European commission!

Exposure to Endocrine Disrupting Chemicals (EDCs) is known to induce a diverse range of health effects. There is now clear evidence that supports an association between EDC exposure and impaired neurodevelopment. However, there is still a considerable lack of scientific knowledge on how endocrine disruption is linked to developmental neurotoxicity (DNT). The ENDpoiNTs consortium therefore aims to combine state-of-the-art in silico and in vitro tools, innovative experimental designs and technologies, and advanced biostatistics on human epidemiological and biomonitoring data to generate scientific insights on the correlative and causal links between endocrine disruption.

Within ENDpoiNTs, we will develop and validate in vitro tools for (developmental) neurotoxicity testing that address sex- and species differences. Focus will be on effects of EDCs on neuronal function, such as assessing altered neuronal network activity using microelectrode arrays (MEAs) and further implementation of human iPSC-derived neuronal co-cultures as model for human neurotoxicity screening.