You are here

Neurotoxicity screening of new psychoactive substances (NPS) using microelectrode array recordings


Zwartsen et al. investigated the effects of 10 new psychoactive substances (NPS) and illicit drugs on spontaneous neuronal activity in rat primary cortical cultures grown on multi-well microelectrode arrays (mwMEAs). All tested drugs induced a rapid and concentration-dependent decrease in neuronal firing, although with marked differences in potency (IC50 ~10 μM for cocaine - IC50 ~235 μM for methylone). This wide range of IC50 values hints towards the existence of a possible structure-activity relationships, which requires further investigation and could aid future risk assessment of emerging NPS (NeuroToxicology).