You are here

Neurotoxicity screening of new psychoactive substances (NPS) using microelectrode array recordings

Body: 

Zwartsen et al. investigated the effects of 10 new psychoactive substances (NPS) and illicit drugs on spontaneous neuronal activity in rat primary cortical cultures grown on multi-well microelectrode arrays (mwMEAs). All tested drugs induced a rapid and concentration-dependent decrease in neuronal firing, although with marked differences in potency (IC50 ~10 μM for cocaine - IC50 ~235 μM for methylone). This wide range of IC50 values hints towards the existence of a possible structure-activity relationships, which requires further investigation and could aid future risk assessment of emerging NPS (NeuroToxicology).