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Different in vitro models to study dopaminergic neurodegeneration

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Heusinkveld and Westerink characterized and compared four different in vitro models for studying pesticide-induced neurodegeneration. While all cell lines showed some neurotoxicity in response to different pesticides, there are strong differences in vulnerability and pesticide-induced effects between the cellular models. These differences are due to differences in intrinsic properties of the cellular models, e.g., differences in the presence or abundance of functional membrane ion channels and receptors, and highlight the importance of choosing the proper cell model (Toxicology in Vitro).