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Neuropharmacological characterization of the new psychoactive substance methoxetamine

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Hondebrink et al investigated the effects of methoxetamine (MXE) on several neurotransmitter receptors, neuronal activity and monoamine transporters using respectively single cell intracellular calcium imaging, micro-electrode array (MEA) recordings and a fluorescence-based plate reader assay. The combined in vitro data demonstrate multiple effects of methoxetamine, including inhibition of monoamine transporters and neuronal network activity, thereby providing a first mechanistic insight to aid the risk assessment of this NPS (Neuropharmacology).