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Inhibitory effects of Tetrodotoxin in rat and human neuronal networks for risk assessment purposes

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Using micro-electrode array (MEA) recordings Kasteel and Westerink demonstrate that Tetrodotoxin (TTX) inhibits neuronal electrical activity in both primary rat cortical cultures and human-induced pluripotent stem cell (hIPSC)-derived neurons with comparable potency (7-10nM). Considering the limited interspecies differences, experimental animal data from literature was used to derive a human acute reference dose of 1.33μg/kg body weight, which corresponds to maximum concentration of TTX in shellfish of 200μg/kg (Toxicology Letters).