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Micro-electrode array (MEA) recordings to investigate neurotoxicity of chronic insecticide exposure

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Dingemans et al used rat primary cortical cultures grown on multi-well micro-electrode arrays (mwMEAs) to investigate effects of chronic (14 days) exposure to different insecticides or methylmercury on neuronal activity. The results demonstrate that chronic exposure to methylmercury, chlorpyrifos and α-cypermethrin inhibited neuronal activity, whereas endosulfan increased neuronal activity and chlorpyrifos-oxon and carbaryl were without effect. Most of these results are comparable with results obtained following acute 30-min exposures, indicating that effects of chronic 14-day exposures on spontaneous neuronal activity in vitro can be predicted by rapid acute screening studies using mwMEAs (NeuroToxicology).